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To determine whether the relationship between phantom limb pain severity and pain-related interference was moderated by age and to compare 2 theoretical perspectives used in the literature to account for age-related differences in the experience of chronic pain.Analysis of survey data provided by 375 adults with lower extremity amputations who reported phantom limb pain.The relationship between phantom limb pain severity and pain-related interference was shown to be moderated by age (β = –.10, p < .05), such that pain predicted interference only in younger adults (β = .44, p < .01). Analysis of age group differences in interference by pain level revealed a large effect when pain was moderate/severe (Cohen's d = 1.23) but not when pain was mild/moderate (Cohen's d = 0.04). Finally, time since amputation emerged as a significant predictor of pain interference above and beyond chronological age.These data suggest that the pain/interference relationship is weaker in older persons, particularly at higher levels of pain. This phenomenon may be driven primarily by temporal experience with pain.