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Affective and adjustment symptoms among compulsive cocaine users have not been thoroughly evaluated, and it is unclear how this subgroup might differ clinically from drug users currently abusing opioids. This study compared subgroups of cocaine and opioid users on global measures of subjective distress, specifically anxiety and depression, and on various self-reported psychopathology symptoms. In contrast to opioid addicts, compulsive cocaine users were characterized by significantly fewer problems with anxiety, depression, and adjustment. Results are consistent with earlier research indicating less severe psychopathology among cocaine abusers than among opioid addicts.