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The purpose of this article is to begin to formulate an acquired immunodeficiency syndrome (AIDS) risk-reduction strategy for use with adolescents. This strategy is based on the state of the art in substance abuse prevention and adolescent pregnancy prevention. The etiology of risk behaviors is discussed, and the history and success of substance abuse prevention and adolescent pregnancy prevention are briefly reviewed A promising approach is the competence enhancement approach, which appears to be generalizable to a variety of problem behaviors. We describe a potential model for AIDS risk reduction There is reason to be cautiously optimistic that this approach may also prove to be effective in preventing AIDS, and we conclude with recommendations for the immediate course of action as well as for future directions in AIDS education.