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This study documented the validity of the Substance Use and Psychiatric Disorder scales of the newly developed Drug Use Screening Inventory (DUSI). Twenty-five adolescents were administered the DUSI. The results were correlated with the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) and DSM-III-R substance abuse symptoms. Significant positive correlations were observed between number of symptoms on the DSM-III-R checklist and severity scores on the Substance Use, Health Status, Psychiatric Disorder, Social Skills, Family System, School, Work, and Peer Relations scales of the DUSI. Number of psychiatric symptoms reported on the K-SADS correlated with severity scores on the Substance Use, Behavior Problems, Health Status, and Psychiatric Disorder scales of the DUSI. The results also indicated that drug use, more than psychiatric disorder, was related to psychosocial disturbances in this sample of adolescents.