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Alcohol researchers have identified several typologies to account for heterogeneity among alcoholics. Because elevated rates of HIV infection have been reported among alcoholics, the strength of associations for HIV risk behavior and 5 typologies of alcoholism (gender, comorbid psychopathology, gamma–delta, family history, and drug abuse) was evaluated. Findings indicated that antisocial personality disorder (ASP) had the strongest average effect size across a number of indicators of HIV risk behaviors (e.g., condom nonuse and injection drug use). Other subtypes involving elevated HIV risk behaviors, although with smaller effect sizes, were gamma–delta, family history of alcoholism, and drug abuse. Results are discussed regarding (a) the use of alcoholism typologies to account for problems associated with, but not defined by, alcohol use behaviors and (b) the use of the ASP and other drug abuse subtypes for interventions to modify HIV risk behaviors.