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The authors investigated the psychometric characteristics of the Quality of Life Interview, Brief Version (QOLI–BV; A. F. Lehman, 1995) in 126 injection drug users recruited for a clinical trial. The QOLI–BV assesses global and domain-specific quality of life. Participants completed the instrument at baseline and 3 and 6 months later. Most scales showed acceptable internal consistency. Convergent and discriminant validity were demonstrated through correlations with the SF-36, the Beck Depression Inventory, and demographic variables. Scale means rose over time, suggesting that the QOLI–BV is sensitive to change. Unexpectedly, lower baseline QOLI–BV scores predicted opiate abstinence at follow-up. The QOLI–BV appears to be an acceptable quality-of-life measure for use in clinical trials of opioid dependence treatments.