Association study of schizophrenia with D11S35 and dopamine D2 receptor gene loci using dinucleotide repeat polymorphisms

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Abstract

We carried out allelic association studies of schizophrenia with D11S35 and dopamine D2 receptor gene loci using dinucleotide repeat polymorphisms. This is the first report of the silver staining method for dinucleotide repeat analysis. There exist ethnic differences in the allele frequencies of these dinucleotide repeat polymorphisms, as was indicated in the previous study with “mini” satellite polymorphisms in other loci. Furthermore, we found a statistically significant association between the allele A2 of the D11S35 locus and schizophrenia. The overall distribution of alleles also shows a significant difference between patients and controls. On the contrary, no significant difference was observed at the dopamine D2 receptor gene locus between patients and controls. Assuming these results are replicated, it would suggest that there is a linkage disequilibrium between the gene causing schizophrenia susceptibility and the D11S35 locus.

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