A Reliable Depression-Like Model in Zebrafish (: Learned HelplessnessDanio rerio: Learned Helplessness): Learned Helplessness

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The zebrafish (Danio rerio) is a teleost fish widely used in neurobehavioral research; however, a depression-like model has not been validated for this species hitherto. Learned helplessness is an animal model of depression, used in rodents, in which the escape–avoidance responses are markedly diminished after exposure to uncontrollable aversive stimuli. This work aims to present a learned helplessness model suitable for zebrafish. Eighteen fish were equally divided into 3 groups, and then submitted to the shuttle box escape test 24 hr after 1 of the following procedures: 60 inescapable shocks (experimental group); 60 min of permanence in the shuttle box without electric shocks (control group); permanence in the collective tank, among the shoal (escape group). The results showed that learning to escape the aversive stimulation was harder for the experimental group, which showed a higher average latency when compared with the other groups (control and escape). Our data show the possibility of use of Learned Helplessness in Zebrafish.

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