The objective of this study was to examine patients' reports of positive quality of life over the course of multiple forms of psychotherapy and disorders. Data from 5 studies using a common assessment battery were pooled to evaluate the magnitude of change in positive quality of life and explore the relation of change in positive quality of life to change in symptoms and how these relations vary by disorder. Positive quality of life was measured at intake, termination, and during 2 posttreatment visits 6 and 12 months following termination. Results revealed that positive quality of life improved moderately over the course of psychotherapy and was sustained through follow-up. Levels of positive quality of life and the degree of change in positive quality of life varied considerably by disorder. There were also moderately sized correlations between changes in positive quality of life and changes in symptomatic response and interpersonal functioning from intake to termination. Implications of the findings for clinical practice and future research are discussed.