This study aimed to compare intraoperative indicators and postoperative efficacy between laparoscopy and open surgery managing benign ovarian tumors. A total of 180 patients with benign ovarian tumor were enrolled; 105 underwent laparoscopy (LA group) and 75 underwent open surgery (OS group). Postoperative parameters were recorded. Preoperative and postoperative serum follicle-stimulating hormone, luteinizing hormone, and estradiol (E2) levels were determined using a BHP9507 chemiluminescence analyzer. The preoperative and postoperative serum C-reactive protein (CRP) level was examined using a QuikRead go CRP analyzer. Serum white blood cell and neutrophil (Ne) percentage were determined using an XT-2000i hematology analyzer. Compared with the OS group, intraoperative blood loss was less and the postoperative anal exhaust time, active time spent out of bed, length of hospitalization, time of indwelling catheter, and time of body temperature returning to normal were shorter in the LA group (all P < 0.001); the number of cases of intraoperative and postoperative complications and analgesia was less in the LA group (all P < 0.05). Six months after operation, serum follicle-stimulating hormone, luteinizing hormone, and E2 levels in the LA group were higher than those in the OS group (all P < 0.05). On day 1 and day 3 after operation, serum white blood cell and CRP levels and Ne percentage in the LA group were lower than those in the OS group (all P < 0.05). Laparoscopy is efficient and safe for managing benign ovarian tumors with comparable results to open surgery, and it is able to alleviate postoperative inflammation and minimize damage to the ovaries.