Effects of beta‐glucans ingestion (Saccharomyces cerevisiae) on metabolism of rats receiving high‐fat diet

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Obesity is considered a chronic, non‐transmittable disease, highly prevailing worldwide, characterized for excessive deposition of body adiposity (Popkin et al., 2012; Luo et al., 2014). In 2012, 69% of the United States population was characterized as obese, and, according to WHO (World Health Organization) the world projection for 2025 is that half of its population will be obese (Who, 2000; Statistics National Center for Health (US), 2014). Obesity has social and physical debilitating consequences and is a risk factor that may trigger different comorbidities such as systemic high blood pressure, dyslipidemia, diabetes mellitus and cardiovascular diseases (Luo et al., 2014).
Functional foods rich in fibres have been used as auxiliary method for body weight and plasma lipid‐lipoprotein profile control, as well as to mitigate insulin resistance (King et al., 2005) that usually takes obese individuals. A large part of studies assign to beta‐glucan (BG) – fibre isolated from plants and leavens cell walls – metabolic and immunomodulatory effects. BG from fungi present glucose β(1–3) and β(1–6) ligations and modulate the immune response (Mantovani et al., 2008). BG isolated from cereals, on the other hand, which have β(1–3) e β(1–4) ligations, show metabolic effects such as triacylglycerol and total cholesterol reduction, in addition to anti‐diabetic activity (Cavallero et al., 2002).
Few studies have investigated the action of BGs isolated from leavens – especially Saccharomyces cerevisiae – on metabolic parameters. Since obese individuals are more prone to aggravation of inflammatory conditions (Schipper et al., 2012), benefits would be doubled: metabolic and immune.
In view of that, this study attempts to investigate the metabolic action of BG from S. cerevisiae in obese Wistar rats, induced with high‐fat diet.
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