Effects of beta‐glucans ingestion (Saccharomyces cerevisiae) on metabolism of rats receiving high‐fat diet
Functional foods rich in fibres have been used as auxiliary method for body weight and plasma lipid‐lipoprotein profile control, as well as to mitigate insulin resistance (King et al., 2005) that usually takes obese individuals. A large part of studies assign to beta‐glucan (BG) – fibre isolated from plants and leavens cell walls – metabolic and immunomodulatory effects. BG from fungi present glucose β(1–3) and β(1–6) ligations and modulate the immune response (Mantovani et al., 2008). BG isolated from cereals, on the other hand, which have β(1–3) e β(1–4) ligations, show metabolic effects such as triacylglycerol and total cholesterol reduction, in addition to anti‐diabetic activity (Cavallero et al., 2002).
Few studies have investigated the action of BGs isolated from leavens – especially Saccharomyces cerevisiae – on metabolic parameters. Since obese individuals are more prone to aggravation of inflammatory conditions (Schipper et al., 2012), benefits would be doubled: metabolic and immune.
In view of that, this study attempts to investigate the metabolic action of BG from S. cerevisiae in obese Wistar rats, induced with high‐fat diet.