Magnetic Barcode Imaging for Contrast Agents

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Abstract

Purpose:

To demonstrate a new MR imaging approach that unambiguously identifies and quantitates contrast agents based on intrinsic agent properties such as r1, r2, r2*, and magnetic susceptibility. The approach is referred to as magnetic barcode imaging (MBI).

Methods:

Targeted and bioresponsive contrast agents were imaged in agarose phantoms to generate T1, T2, T2*, and quantitative susceptibility maps. The parameter maps were processed by a machine learning algorithm that is trained to recognize the contrast agents based on these parameters. The output is a quantitative map of contrast agent concentration, identity, and functional state.

Results:

MBI allowed the quantitative interpretation of intensities, removed confounding backgrounds, enabled contrast agent multiplexing, and unambiguously detected the activation and binding states of bioresponsive and targeted contrast agents.

Conclusion:

MBI has the potential to overcome significant limitations in the interpretation, quantitation, and multiplexing of contrast enhancement by MR imaging probes. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.

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