Does waiting after peri‐prostatic nerve block reduce pain during transrectal ultrasound‐guided prostate biopsy? A randomized controlled trial

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First introduced by Hodge et al. in 1989, systematic transrectal ultrasound (TRUS)‐guided prostate biopsy represented a turning point in the diagnosis of prostate cancer and it rapidly became the standard method for the detection of the disease.1 Despite significant recent advances in other methods of prostate cancer detection such as multiparametric MRI, fusion and transperineal prostate biopsies, TRUS‐guided prostate biopsy is still widely performed, primarily in an outpatient setting.2
In 1996, Nash et al. first reported that peri‐prostatic nerve block (PNB) allow patients to experience less pain associated with TRUS‐guided prostate biopsy.3 Several other studies have since reported similar findings using various local anaesthetic mixtures and PNB techniques.4 However, no study has specifically addressed whether a short, clinically sufficient and manageable time delay provides any additional benefit over immediate TRUS‐guided prostate biopsy. This study aims to determine if a short, clinically sufficient and manageable delay after PNB prior to biopsy reduces pain in men undergoing TRUS‐guided prostate biopsy.

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