A Fast Chemical Exchange Saturation Transfer Imaging Scheme Based on Single-Shot Spatiotemporal Encoding

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Abstract

Purpose:

To design a new approach that can not only keep the spatial and temporal resolution but also have better built-in immunity to magnetic field inhomogeneity and chemical shift effects than the single-shot echo planar imaging (EPI) for chemical exchange saturation transfer (CEST) MRI.

Method:

The single-shot spatiotemporally encoded (SPEN) MRI sequence was combined with a continuous wave saturation pulse for fast CEST MRI (CEST-SPEN MRI). The resulting images were super-resolved reconstructed by a hybrid method that solves the l1 norm minimization together with total variation (TV) regularization. Partial Lorentzian fitting was used to analyze the subsequent Z-spectra.

Results:

Experimental results of a creatine phantom and in vivo tumor rat brains show that CEST-SPEN MRI has good capability in providing CEST-based and NOE-based contrast images.

Conclusions:

Compared with CEST-EPI, CEST-SPEN MRI has better immunity to magnetic field inhomogeneity and provides better contrast images within identical acquisition time, especially under an identical inhomogeneous field.

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