Stable polyanhydride synthesized from sebacic acid and ricinoleic acid

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Abstract

Poly(anhydride) are unstable and prone to hydrolytic degradation and depolymerisation via anhydride interchange. They are stored at − 20 °C, packed under inert atmosphere until use. We synthesized a new poly(anhydride) from ricinoleic (RA) and sebacic (SA) acid with alternating ester-anhydride structure that is stable at 25 °C for over 18 months. The copolymer is also stable in chloroform solution and under γ-irradiation. The polymer hydrolyses through anhydride cleavage lasting ˜ 7 days to form oligoesters, which are stable for > 30 days. The release of gentamycin from the synthesized alternate polymer matrix is sustained compared to the random copolymer.

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