Clinical presentation, treatment and outcome of focal segmental glomerulosclerosis in Far North Queensland Australian adults

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Excerpt

Focal segmental glomerulosclerosis (FSGS) is a pathologic term that is characterzsed by the presence of focal and segmental glomerular sclerotic lesions. It has a complex aetiology and can be classified into primary and secondary FSGS. Primary FSGS is diagnosed in over 80% of cases and is a diagnosis of exclusion.1 The disease trends towards progressive decline of renal function to end stage kidney disease (ESKD) within 5–10 years in over 50% of cases.2
In 2011, FSGS was the second leading cause of all new glomerulonephritis cases resulting in ESKD in Australia.4 These rates are on the rise internationally with some countries reporting a 3–13 fold increase in incidence over the past two decades.5
The increasing incidence of ESKD attributable to FSGS and its associated burden on patients and their families that has prompted renewed interest in this disease.
The purpose of the study was to describe the clinical features, treatment and outcomes of primary and secondary FSGS in Far North Queensland Australian adults and to identify any predictors of disease progression and all‐cause mortality.
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