Myocardial effective transverse relaxation time Correlates with left ventricular wall thickness: A 7.0 T MRI study

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Myocardial effective relaxation time is commonly regarded as a surrogate for myocardial tissue oxygenation. However, it is legitimate to assume that there are multiple factors that influence . To this end, this study investigates the relationship between and cardiac macromorphology given by left ventricular (LV) wall thickness and left ventricular radius, and provides interpretation of the results in the physiological context.


High spatio-temporally resolved myocardial CINE mapping was performed in 10 healthy volunteers using a 7.0 Tesla (T) full-body MRI system. Ventricular septal wall thickness, left ventricular inner radius, and were analyzed. Macroscopic magnetic field changes were elucidated using cardiac phase–resolved magnetic field maps.


Ventricular septal changes periodically over the cardiac cycle, increasing in systole and decreasing in diastole. Ventricular septal wall thickness and showed a significant positive correlation, whereas the inner LV radius and were negatively correlated. The effect of macroscopic magnetic field gradients on can be considered minor in the ventricular septum.


Our findings suggest that myocardial is related to tissue blood volume fraction. Temporally resolved mapping could be beneficial for myocardial tissue characterization and for understanding cardiac (patho)physiology in vivo. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.

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