Gaussian signal relaxation around spin echoes: Implications for precise reversible transverse relaxation quantification of pulmonary tissue at 1.5 and 3 Tesla
To characterize the reversible transverse relaxation in pulmonary tissue and to study the benefit of a quadratic exponential (Gaussian) model over the commonly used linear exponential model for increased quantification precision.Methods:
A point-resolved spectroscopy sequence was used for comprehensive sampling of the relaxation around spin echoes. Measurements were performed in an ex vivo tissue sample and in healthy volunteers at 1.5 Tesla (T) and 3 T. The goodness of fit using and the precision of the fitted relaxation time by means of its confidence interval were compared between the two relaxation models.Results:
The Gaussian model provides enhanced descriptions of pulmonary relaxation with lower by average factors of 4 ex vivo and 3 in volunteers. The Gaussian model indicates higher sensitivity to tissue structure alteration with increased precision of reversible transverse relaxation time measurements also by average factors of 4 ex vivo and 3 in volunteers. The mean relaxation times of the Gaussian model in volunteers are = (1.97 ± 0.27) msec at 1.5 T and = (0.83 ± 0.21) msec at 3 T.Conclusion:
Pulmonary signal relaxation was found to be accurately modeled as Gaussian, providing a potential biomarker with high sensitivity. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.