Acceleration-selective arterial spin labeling for intracranial MR angiography with improved visualization of cortical arteries and suppression of cortical veins

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A new approach for intracranial MR angiography (MRA) is introduced, using acceleration-selective arterial spin labeling (AccASL). The aim of this study was to investigate the arterial visualization and venous suppression using AccASL.


Intracranial MRA images obtained by AccASL and time-of-flight (TOF) were compared in seven healthy volunteers and one patient with occlusion of the terminal portion of the left internal carotid artery. The volunteer images were assessed by measuring the contrast-to-noise ratio (CNR) between the middle cerebral artery (MCA) and white matter (WM) and between the confluence of sinuses and WM. Additionally, visualized peripheral arteries were counted and qualitative scoring of the MCA visualization and vein signal contamination was conducted.


The CNR at the M4 branch and the number of visualized arteries was significantly higher using AccASL compared with that in TOF (P < 0.05). In the qualitative comparison, the score for artery visualization was higher using AccASL (P < 0.05), while minimizing signal contamination by cortical veins. Additionally, in patient examination, the collateral flow visualization was better with AccASL.


AccASL enables better efficiency for visualizing peripheral arteries compared with TOF, while suppressing cortical vein signal. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.

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