Corneal Sublayers Thickness in Patients With Mitral Valve Prolapse

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The aim of this study was to compare the thickness of each corneal sublayer in patients with mitral valve prolapse (MVP) and healthy individuals.


A total of 38 eyes from 38 patients with MVP and 34 eyes from 34 age- and sex-matched healthy individuals were included in this study. The thickness of the corneal epithelium, Bowman layer, stroma, and Descemet membrane—endothelium complex were measured on the central cornea (i.e., corneal apex) and both the inferior and superior halves of the cornea with anterior segment module of spectral domain optical coherence tomography.


No statistically significant differences emerged between the study and control groups in terms of Bowman layer thickness in the central cornea and the cornea's superior half (P=0.092 and P=0.128, respectively). However, in the inferior half of the cornea, Bowman layer thickness among patients with MVP was 11.95±2.34 μm (range 7–16 μm) and in the control group was 13.03±1.62 μm (range 10–16 μm), which made for a statistically significant difference (P=0.025).


Our study revealed thinning of Bowman layer in the inferior half of the cornea in patients with MVP.

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