Acute kidney injury post‐major orthopaedic surgery: A single‐Centre case–control study
There are a handful of studies looking at risk factors associated with AKI post‐MOS.4 Previous studies have found an incidence of around 9%6 with an increased risk during emergency procedures.4 For patients undergoing non‐cardiac surgery with prior normal renal function, the incidence less than 1%11 recognized risk factors of AKI include age, chronic kidney disease (CKD), medications such as angiotensin converting enzyme inhibitor (ACE‐I) or angiotensin receptor blockers (ARB), diuretics and a history of diabetes, hypertension and obesity. Less understood is the association between non‐steroidal anti‐inflammatory drugs (NSAID) administration and the risk of AKI. At our institution, parenteral parecoxib, a NSAID that inhibits the enzyme cyclo‐oxygenase 2 was often administered to patients with an estimated glomerular filtration (eGFR) rate of greater than 60 mL/min during MOS. Given the long‐term morbidity and mortality associated with AKI, the aim of the study was to look at factors that were associated with AKI in the context of orthopaedic surgery at our institution.