The relationship between proteoglycan inhibition via xylosyltransferase II silencing and the implantation of salivary pleomorphic adenoma

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Excerpt

Salivary pleomorphic adenoma (SPA) is one of the most common epithelial tumours of the salivary glands. Although the tumour is considered to be benign, it does have the potential to exhibit certain malignant characteristics, such as recurrence and implantation, and is therefore recognized as a borderline tumour 1.
SPA contains epithelial elements that are intermingled with tissue showing a mucoid, myxoid or chondroid appearances. These tissues are enriched with proteoglycans secreted by neoplastic myoepithelial cells 2.
Most recent studies on SPA have focused on the underlying molecular mechanisms and gene expression and genetic analysis 3. However, the relationship between proteoglycan inhibition and SPA implantation has not yet been reported.
In this study, xylosyltransferase II (XT‐II), a xylosyltransferase I (XT‐I) isoform involved in the initial step of the proteoglycan biosynthesis, was silenced via RNAi. The inhibition of proteoglycan biosynthesis was followed by both in vitro and in vivo assessment of SPA invasion, migration and implantation in nude mice.
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