NaV1.7 as a pain target – From gene to pharmacology

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Abstract

NaV1.7, a subtype of the voltage-gated sodium channel family that is highly expressed in peripheral sensory neurons, remains one of the most promising targets for the treatment of pain. However, despite compelling genetic evidence supporting a key role for NaV1.7 in regulating excitability of peripheral sensory neurons, the development of truly subtype-selective inhibitors has been challenging. Here, we discuss complexities surrounding targeting NaV1.7 pharmacologically for treatment of pain and explore future opportunities for development of effective analgesic NaV1.7 inhibitors.

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