Evaluation of Teicoplanin Trough Values After the Recommended Loading Dose in Children With Associated Safety Analysis
This study evaluated whether the recommended teicoplanin loading dose (3 loading doses of 10 mg/kg every 12 hours) achieves a 15–30 μg/mL trough levels in 26 children (2−16 years). In addition, we examined the incidences of renal impairment and hepatic dysfunction in children treated with teicoplanin.Methods:
This retrospective study was conducted between October 2008 and March 2014.Results:
The percentage of patients with a trough level <10 and <15 μg/mL were 15.4% (4/26) and 46.2% (12/26), respectively. There were significant correlations between age and concentration/cumulative loading dose (C/D) ratio (P = 0.045), serum creatinine and C/D ratio (P < 0.001) and estimated glomerular filtration rate and C/D ratio (P = 0.005). Serum creatinine was significantly lower when trough levels were <15 μg/mL compared with ≥15 μg/mL. The incidences of renal impairment and hepatic dysfunction were 2.3% and 5.8%, respectively, with no significant difference between <20 and ≥20 μg/mL trough-level groups.Conclusions:
The recommended loading dose may be insufficient to achieve 15–30 μg/mL in children with normal renal function. In addition, the target trough level ≥20 μg/mL for deep-seated infections seems to be safe in children.