Pseudocarcinomatous Epithelial Hyperplasia Induced by Imiquimod: A Mimic of Cutaneous Squamous Cell Carcinoma

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Pseudocarcinomatous hyperplasia (PCH), also known as pseudoepitheliomatous hyperplasia, consists of nonneoplastic, epidermal and/or adnexal hyperplasia that can mimic squamous cell carcinoma both clinically and histopathologically. Various inciting factors have been reported for PCH, including trauma, infection, inflammatory disorders, and neoplasia.1 Pseudocarcinomatous hyperplasia can be seen in patients with excessive iodine or bromine exposure (halogenodermas), but has not been otherwise reported as a medication side effect. We describe the first case of cutaneous PCH resulting from imiquimod and highlight a potential diagnostic pitfall.
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