Understanding risk factors for prostate cancer is an important step towards personalized, risk-adapted early detection and prevention. Epidemiological studies, which are commonly used to identify risk factors, are prone to detection bias. This bias could substantially affect the observed relationship between putative risk factors and prostate cancer diagnosis.
Refers to Tangen, C. M. et al. Biases in recommendations for and acceptance of prostate biopsy significantly affect assessment of prostate cancer risk factors: results from two large randomized clinical trials. J. Clin. Oncol. http://dx.doi.org/10.1200/JCO.2016.68.1965 (2016)