Any endocrinologist with teaching responsibilities (and who doesn’t?) will, I’m sure, identify with the Mark Twain witticism that ‘What gets us into trouble is not what we don’t know. It's what we know for sure that just ain’t so.’ Several times a year, we come face to face with new information that forces us to confront deeply held beliefs and modify our thinking on the matter in question. That said, the appropriate attitude of mind for the practicing endocrinologist or research scientist dealing with endocrine issues is, whenever presented with a fact, ask ‘what are the data supporting that fact?’ All too often, one discovers the data are thin or nonexistent. Further, by asking the question, one is challenged to think of approaches that may shed new light on the issue. Such an attitude is what underlies the scientific method, and is the engine that opens up whole new fields of understanding. Often times, it is a new technology that allows age old questions to be probed with greater precision. Other times, insights are gained, as Nobel laureate Albert Szent-Gyorgi said, by seeing ‘what everybody else has seen, and to think what nobody else has thought.’ What I particularly like about Current Opinion in Endocrinology, Diabetes and Obesity, is that the periodical provides a platform for such questioning. Opinion, after all, is the second word in the journal's name! This month's Current Opinion in Endocrinology, Diabetes and Obesity includes several contributions that shed such new light on issues integral to beta cell biology, diabetes pathogenesis, end-organ complications, and even the financial structure within which diabetes care is delivered.