Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents

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Abstract

OBJECTIVES:

Our aim was to investigate the association between the triglycerides/glucose index (TyG index) and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) in the prediction of insulin resistance (IR) among adolescents.

METHODS:

We conducted a cross-sectional study among 221 Korean adolescents (168 males and 53 females aged 9–13 years) from May to June 2014 in Chung-ju city. The TyG index was calculated as ln [triglycerides (mg dl-1) × fasting glucose (mg dl-1)/2]. IR was defined using HOMA-IR >95th percentile for age and sex.

RESULTS:

In the IR group, weight, body mass index (BMI), waist circumference, body fat, fasting insulin, fasting plasma glucose, triglyceride levels and triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) were significantly higher than that in the non-IR group. The TG index was significantly different between the IR group (n = 22) and non-IR group (n = 199), at 8.43 ± 0.45 and 8.05 ± 0.41, respectively (P < 0.001). The TyG index was well correlated with HOMA-IR (r = 0.41; P < 0.001) and showed a strong positive association with TG/HDL-C (r = 0.84; P < 0.001). The cut-off of the TyG index for diagnosis of insulin resistance was 8.18.

CONCLUSIONS:

The TyG index is a simple, cost-effective surrogate marker of insulin resistance among adolescents compared with HOMA-IR.

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