Translational studies identify long-term impact of prior neonatal pain experience

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A comprehensive assessment of pain extends beyond measuring the intensity of pain to also include: site and radiation of pain; onset, aggravating and relieving factors; character of pain; associated symptoms; effect on activities and sleep; treatment and response; medical history; and factors influencing symptomatic treatment, such as beliefs and expectations, coping response and presence of anxiety or mood disorders, and family expectations.175 Similarly, in clinical analgesic trials for chronic pain, detailed phenotyping of patients may provide information related to factors that predict not only the risk of persistent pain, but also the response to treatment.55 This is particularly relevant given emerging data that mechanisms and efficacy of potential interventions for neuropathic pain differ between males and females.124 Core phenotyping domains recommended as part of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) include: pain qualities; psychosocial measures; sleep; and quantitative sensory testing, including conditioned pain modulation.
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