Effect of L-thyroxine supplementation on very low birth weight infants with transient hypothyroxinemia of prematurity at 3 years of age

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Abstract

OBJECTIVE:

To evaluate the effects of levothyroxine (L-T4) supplementation on growth and neurodevelopmental outcomes at 3 years of age in very low birth weight (VLBW) infants with transient hypothyroxinemia of prematurity (THOP).

STUDY DESIGN:

VLBW infants with plasma thyroid-stimulating hormone concentrations < 10 mIU l-1 and free thyroxine concentrations < 0.8 ng dl-1 were defined as having THOP and randomly assigned to the Treated (20 infants) or Untreated (31 infants) group. The Treated group received L-T4 at a dose of 5 μg kg-1 day-1. Growth and neurodevelopmental outcomes at 3 years of age were compared between the two groups.

RESULTS:

There were no significant differences in body length, body weight or head circumference mean s.d. scores or in neurodevelopmental outcomes between the two groups.

CONCLUSION:

L-T4 supplementation in VLBW infants with THOP demonstrated no beneficial effect at 3 years of age.

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