Neurobiological basis for pain vulnerability: why me?

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Excerpt

A great deal of mechanistic work conducted in pain research is concerned with answering the question of why a certain stimulus should be perceived as painful or how the nervous system in a chronic pain state differs from the healthy norm. In these kinds of studies, individual differences in perception are usually seen as a nuisance—a distraction from any “real signal.” And indeed, there is a large amount of noise to contend with: pain experiences are extremely variable, both in health and disease.
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