68Ga-Exendin-4 PET/CT in Evaluation of Endoscopic Ultrasound–Guided Ethanol Ablation of an Insulinoma

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A 32-year-old man with endogenous hyperinsulinemic hypoglycemia was clinically diagnosed with an insulinoma. Conventional imaging result was negative, and a previous exploratory laparotomy with distal pancreatectomy failed to detect the tumor. 68Ga-exendin-4 PET/CT showed a lesion with intense radioactivity in the head of the pancreas suggestive of an insulinoma, and endoscopic ultrasound-guided ethanol ablation was performed. Postablation evaluation with 68Ga-exendin-4 PET/CT showed markedly decreased radioactivity of the tumor. The symptoms and blood glucose monitoring also suggested partial response of the insulinoma.

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