It's what's on the inside that counts: evidence for intracellular G-protein–coupled receptor signaling in inflammatory pain

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The importance of G-protein–coupled receptor (GPCR) signaling in the context of pain therapy is well established.5 However, an exciting new report this month by Vincent et al.8 challenges the assumption that the main pool of nociceptive GPCRs is located in the plasma membrane. This report demonstrates the presence of unique subcellular pools of GPCRs, which are activated by endogenous ligands and are upregulated after inflammatory injury. These data have important implications for those involved in drug development and for those interested in injury-induced protein changes.
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