Collaboration to Accelerate Proteogenomics Cancer Care: The Department of Veterans Affairs, Department of Defense, and the National Cancer Institute's Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Network

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Advances in molecular profiling of patients are difficult to test and rapidly deploy in the current translational pipeline, while the hand‐off to determine clinical utility in large healthcare systems using real‐world evidence remains a challenge. The Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Network represents an important interagency partnership that brings together the scientific and technical capabilities of the National Cancer Institute (NCI) and the Departments of Defense (DoD), and Veterans Affairs (VA) to create the nation's first healthcare enterprise where proteomic analysis complements genomic sequencing in cancer patients to inform targeted therapy decision‐making.
This collaboration establishes a new paradigm that merges the silos of research expertise and clinical care improvement to enable an environment of rapid iterative learning and direct implementation into clinical care. The unique capabilities of each member of this tri‐agency coalition synergize to accelerate the pace of discovery, prospectively validate those findings in defined patient cohorts, and disseminate generalizable results as best practices and guidelines for adoption across a healthcare system. By combining resources, intellectual capacity and technologies in research, clinical care, and information dissemination in an integrated manner, the NCI, DoD, and VA are poised to provide a model of cancer care for the entire nation.
The NCI contribution to the coalition includes the expertise and availability of proteogenomic research programs that advance our understanding of the molecular basis of cancer and its treatment, clinical trials of emerging therapies that capitalize on these advances, and compute infrastructure that enables data storage, sharing, and analysis. Resources brought to the task by the DoD, particularly through the Walter Reed National Military Medical Center and Uniformed Services University, include high throughput sequencing and state‐of‐the‐art biobanking. Within the VA the integrated capacities of clinical care and a full clinical research infrastructure provides a unique ecosystem that will serve as the “dry laboratory” where research is more rapidly translated into care in the context of a learning healthcare system. The proposed collaboration extends and aligns each organization's ongoing activities to accelerate discovery and translation of new knowledge in cancer.
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