Pleural Metastasis From Cutaneous Malignant Melanoma

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Excerpt

Metastatic cutaneous melanoma, the incidence of which continues to increase worldwide1 is associated with a high morbidity and mortality. Although only accounting for 4% of dermatologic malignancies, it is responsible for 80% of skin cancer–related deaths.2 Common sites of metastasis include lung, liver, bone, and brain.3,4 Only 2% of melanoma patients with intrathoracic metastasis develop a malignant pleural effusion.5 It is known that elevated serum lactate dehydrogenase (LDH) can be used as an adverse prognostic factor in stage IV cutaneous melanoma.6,7 We present a case of metastatic cutaneous melanoma to the pleura in a gentleman with normal pleural fluid and serum LDH levels, a possible indicator of favorable prognosis.

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