This experiment was conducted to evaluate the effect of diets with different energy and emulsifier (Lipidol, active ingredient: lysophospholipids; LPL) levels on growth performance, nutrient digestibility, body composition, and serum profile in broilers. A total of 864 one-day-old male Ross 308 broilers (45.3 ± 0.6 g) was used in a 28-day experiment. Broilers were allotted to a 2 × 3 factorial arrangement design with 2 levels of energy (starter: ME = 2,950 kcal/kg for energy reduced diet and 3,050 kcal/kg for basal diet; finisher: ME = 3,100 kcal/kg for energy reduced diet and 3,200 kcal/kg for basal diet) and 3 levels of emulsifier supplementation (zero, 0.05, and 0.10%) according to their initial BW. There were 8 replicate cages per treatment with 18 broilers per cage. Broilers fed basal diets had higher (P < 0.05) body weight gain (BWG, d zero to 14) and lower (P < 0.05) feed conversion ratio (FCR, d zero to 14 and d zero to 28) than those fed reduced energy diets. Broilers fed LPL supplementation diets also had higher (P < 0.05) BWG (d zero to 14) and lower (P < 0.05) FCR (d zero to 14, d 15 to 28, and d zero to 28) than those fed without LPL supplementation diets. On d 14, the apparent total tract digestibility (ATTD) of DM, nitrogen (N), and gross energy (GE) was increased (P < 0.05) by LPL supplementation. The low density lipoprotein cholesterol, total cholesterol, and triglycerides concentrations also were decreased (P < 0.05) by LPL supplementation on d 14. The relative weight of abdominal fat was higher (P < 0.05) in basal diet treatments, but lower (P < 0.05) in LPL supplementation treatments. In conclusion, LPL supplementation can increase growth performance and nutrient digestibility, decrease cholesterol and triglycerides concentration in the starter period, and decrease the abdominal fat percentage in broilers.