Serious concerns regarding a meta-analysis of preexposure prophylaxis use and STI acquisition

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An article in AIDS by Kojima and colleagues posits that high unadjusted rates for sexually transmitted infections (STIs) among preexposure prophylaxis (PrEP) users in five studies, compared with low unadjusted rates for PrEP nonusers in 14 studies [1], reflect increased sexual risk behaviors following PrEP uptake. They conclude with a call to reconsider how this important HIV prevention strategy is implemented.
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