Addressing concerns regarding preexposure prophylaxis meta-analysis

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We appreciate the commentary [1] about our analysis and agree that preexposure prophylaxis (PrEP) for HIV is a critical strategy for the prevention of acquisition of HIV infection. The authors of the commentary [1] acknowledge the importance of our findings; however, they raise concerns that our findings might partially be explained by the overall general increase in incidence of sexually transmitted infections (STIs) among MSM since 2000 and the increased frequency of STIs testing among PrEP users. Furthermore, they raise concerns about the ability to replicate findings because of limited data availability and distortions made by an advocacy group using the findings to promote their own agenda.
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