Deoxycholic Acid

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I recently received the latest edition of Dermatologic Surgery which included a supplemental section devoted to deoxycholic acid.
In reading the articles, I believe that most were remiss in not including as a reference the study that Dr. Michael Morgan and I did using the combination of phosphatidyl choline (PC) and deoxycholate (DC). Our work was the first to demonstrate the histologic changes caused by PC and DC in humans.
“J of Cosmetic and Laser Therapy; Volume 7, Issue 1, 2005, 17–19.”
In addition, the articles fail to note that DC is available through compounding pharmacies at a far lower cost than ATX 101. Such compounded DC would probably demonstrate similar efficacy. It should be noted that in 2010, the Food and Drug Administration (FDA) did issue warning letters primarily regarding misleading claims of efficacy. The FDA expressed concern regarding safety issues in spite of the use of DC in drug preparations such as amphotericin B and influenza vaccine.
Also in 2010, the FDA did acknowledge that PC/DC drugs were being used legally in other countries primarily in intravenous form. The studies on ATX 101 have confirmed the efficacy of DC and safety of DC, so one could logically assume that a certified compounding pharmacy could provide DC that is safe to utilize. The use of certified compounding pharmacies is legal in the United States.
Last, I would suggest that a “mini liposuction” under local anesthesia would provide an equally good cosmetic result in a shorter time, with less adverse reaction and at a far lower expense to the patient.
One might contend that the use of injectable DC is “noninvasive” or “nonsurgical,” but patients often feel that multiple needle injections of material that is irritating, painful, and causes marked erythema and edema are invasive and surgical. To perform submental liposuction, the surgeon could use a single 3-mm or smaller submental entry, and with a micro cannula could perform the complete procedure in a few minutes under local anesthesia. At worst, this would be considered “minimally invasive” surgery.
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