Maintenance therapy with salicylates is associated with aortic stiffening in patients with inflammatory bowel disease

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In a meta-analysis recently published in Journal of Hypertension[1], we found that patients with inflammatory bowel disease (IBD) have an increased carotid–femoral pulse wave velocity (cf-PWV). This finding is in accordance with our previous works [2,3] and with a recent independent meta-analysis [4]. The stiffening of central elastic arteries supports the evidence for an elevated cardiovascular risk in patients with IBD [5] and is of great clinical importance because it helps explaining the IBD paradox, that is the increased cardiovascular risk in a population with a low prevalence of traditional cardiovascular risk factors [6]. In this regard, we suggested that chronic inflammation could be responsible for arterial stiffening in patients with IBD [1–3,7]. Recently, it has been reported that stiffness parameters are significantly higher in IBD patients treated with salicylates [8]. This finding is in accordance with our hypothesis of a lack of efficacy of salicylates in protecting IBD patients from arterial stiffening [3], contrasting with the destiffening effect of anti-TNFα therapy, as reported in our meta-analysis [1].

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