Maintenance therapy with salicylates is associated with aortic stiffening in patients with inflammatory bowel disease
In a meta-analysis recently published in Journal of Hypertension, we found that patients with inflammatory bowel disease (IBD) have an increased carotid–femoral pulse wave velocity (cf-PWV). This finding is in accordance with our previous works [2,3] and with a recent independent meta-analysis . The stiffening of central elastic arteries supports the evidence for an elevated cardiovascular risk in patients with IBD  and is of great clinical importance because it helps explaining the IBD paradox, that is the increased cardiovascular risk in a population with a low prevalence of traditional cardiovascular risk factors . In this regard, we suggested that chronic inflammation could be responsible for arterial stiffening in patients with IBD [1–3,7]. Recently, it has been reported that stiffness parameters are significantly higher in IBD patients treated with salicylates . This finding is in accordance with our hypothesis of a lack of efficacy of salicylates in protecting IBD patients from arterial stiffening , contrasting with the destiffening effect of anti-TNFα therapy, as reported in our meta-analysis .