IBD: Genetic differences in Crohn's disease susceptibility and outcome

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Abstract

A new genome-wide association study (GWAS) has been conducted to discover genetic contributions that can explain disease prognosis in Crohn's disease. This understudied area deserves attention for discovering genetic variants responsible for disease severity, as well as encouraging scientists to analyse or reanalyse GWAS data using various clinically important endophenotypes.

Refers to Lee, J. C. et al. Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat. Genet.49, 262-268 (2017)

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