HIV-infected children with hepatomegaly and ascites: is there something more than an infection?

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HIV infection is known to predispose to venous thromboembolism (VTE), the risk ranging from 2% to 10% in adults [1]. A thrombotic state occurs because of abnormalities of coagulation system and platelet activation, endothelial dysfunction, opportunistic infections and antiretroviral therapy (ART) [2]. However, there are only a few reports of thrombosis in HIV-infected children [3–5] and, to the best of our knowledge, portal vein thrombosis has never been reported [6–8]. We report two children who developed this very uncommon complication.

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