Gene therapy, a promising treatment for familial hypercholesterolaemia

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Excerpt

Cardiovascular diseases especially coronary heart disease (CHD) is a primary cause of death worldwide [1]. Epidemiological studies have shown that smoking, hypertension, diabetes and high plasma concentration of LDL cholesterol (LDL-C) are strongly associated with CHD [2]. Disorders of extremes of LDL-C such as familial hypercholesterolaemia indicate a causal relationship between LDL-C and CHD [3].
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