The onward march of PCSK9 inhibition

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There is indisputable evidence that the LDL cholesterol (LDL-c) is a principle driver of atherosclerotic vascular disease and thus is a key target for intervention [1▪▪]. Moreover, insights from Mendelian randomization studies suggest that the magnitude of the clinical benefits accruing relates more to the extent of LDL-c lowering rather than the mechanism of how so achieved [2▪▪].
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