There is mounting evidence that osteoblasts are involved in the regulation of global energy metabolism. Although osteocalcin signalling remains important, the complexity of systemic energy storage and expenditure makes it likely that hitherto unknown factors are also involved in osteoblast-mediated regulation of metabolism.
Refers to Yao, Q. et al. Wnt/β-catenin signalling in osteoblasts regulates global energy metabolism. Bone 97, 175–183 (2017)