Severe Case of Tumor Lysis Syndrome Presenting Spontaneously in a Metastatic Pancreatic Adenocarcinoma Patient

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To the Editor:
Tumor lysis syndrome (TLS) is a well-known oncological emergency which is commonly witnessed after initiation of treatment in chemotherapy-sensitive malignancies like leukemias and high-grade lymphomas. It presents with metabolic derangements, such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, resulting from massive or sudden breakdown of malignant cells. Tumor lysis syndrome is seldom seen in solid tumors and furthermore, treatment-naive spontaneous TLS is even rarer. We describe a severe case of spontaneous TLS in metastatic pancreatic adenocarcinoma which is rarely reported.
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