Genetic Alterations inTRAF3andCYLDThat Regulate Nuclear Factor jB and Interferon Signaling Define Head and Neck Cancer Subsets Harboring Human Papillomavirus

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Recent genomic studies of head and neck squamous cell carcinoma by The Cancer Genome Atlas as well as other groups identified deletions or mutations in tumor necrosis factor receptor-associated factor 3 (TRAF3) and cylindromatosis lysine 63 deubiquitinase (CYLD) that previously were implicated in nuclear factor-κB (NF-κB) and antiviral interferon responses. In this issue, Hajek et al find genomic alterations in TRAF3/CYLD define distinct subsets of human papillomavirus-positive head and neck squamous cell carcinomas with associated activation of transcription factor NF-κB, episomal human papillomavirus infection of tumors, and improved patient survival.

See also pages 1778-90.

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