GLOMERULAR DISEASE: Crescentic glomerulonephritis: beyond the immune system

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Abstract

T cells mediate injury in glomerulonephritis but mice devoid of T cells and B cells can also develop this disease. A new study shows that expression of the cytokine receptor common subunit γ and IL-15 in podocytes protects against crescentic glomerulonephritis, independent of B cells, T cells and natural killer cells.

Refers to Luque, Y. et al. Glomerular common gamma chain confers B-and T-cell-independent protection against glomerulonephritis. Kidney Int.http://dx.doi.org/10.1016/j.kint.2016.10.037 (2017)

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