Biomarkers and anastomotic leakage in colorectal surgery: C‐reactive protein trajectory is the gold standard
Clinical signs of anastomotic leakage are generally unreliable and tend to present late,1 so in view of this, a number of tools have been assessed, for utility in diagnosing anastomotic leakage at an early stage. Imaging, peritoneal cytokine levels and serum biomarkers of inflammation have all been proposed as methods in order to provide early detection of anastomotic leakage.1
For the purpose of this study, we chose four inflammatory serum biomarkers: C‐reactive protein (CRP), procalcitonin (PCT), white cell count (WCC) and gamma‐glutamyl transferase (GGT) and sought to assess their utility with respect to reliably predicting colorectal anastomotic leakage. In particular, we sought to determine whether the rate of change, or trajectory, of these biomarkers was predictive of anastomotic leak as defined by the need for intervention with surgery or radiological drainage.