A recent trial in critically ill children found no benefit from lowering blood levels of glucose to 4.4-6.1 mmol/l compared with tolerating hyperglycaemia. The achieved levels of glucose, however, overlapped considerably between the tight and liberal glycaemic control groups, which might explain the lack of benefit. Moreover, liberal use of antibiotics could have resulted in a false low rate of infections.
Refers to Agus, M. S. et al. Tight glycemic control in critically ill children. N. Engl. J. Med. 376, 729-741 (2017)